Nickel one of the critical factors and a poisonous

Document Type : Original Article


Department of Microbiology, ADT’s, Shardabai Pawar Mahila Arts, Commerce and Science College, Shardanagar, Baramati-413 115, Maharashtra, India



Heavy metal pollution according to natural and anthropogenic resources is an international problem. Amongst heavy metals, nickel is a contaminant, which collects in soils, plants, animals, and aquatic systems. The nickel (Ni) concentration ranges in soil and drinking water is from 10 – 1000ppm and 6µg/l orderly. The nickel concentration in natural vegetation is between 0.05 and 5mg/kg of dry weight. The nickel portion penetrating the human respiratory is between 0.1 and 0.7µg/day. 100-200 µg of nickel is used each day including nickel cookery dishes. Everyday input of nickel from food is approximately 170µg orderly. The nickel level in seawater and river includes about 0.5 to 2ppb and 0.3ppb orderly. The normal smoke of a cigarette includes approximately 0.04 to 0.58 µg of nickel. Nickel is in the milk of humans and cows at a concentration between 0.001 to 0.1 mg/l orderly. The nickel resources include rocks and soil weathering, forest fires, fertilizers, industrial garbage, sewage, and sludge that includes a high amount of nickel. Nickel is an important factor needed for the plant's healthy growth, animals, and soil microbes, influences the photosynthetic processes of high plants, generates critical and chronic illnesses in humans, and decreases soil fertility. This study demonstrates the effects, significance, and poison of nickel.


  1. Akhtar, N., Iqbal J and Iqbal M. (2004). Removal and recovery of nickel (II) from aqueous solution by loofa

    sponge – immobilized biomass of Chlorella sorokiniana: Characterization studies. J. Haz. Mat. 108 : 85 – 94

    Baker, A. J. M., McGrath, S. P., Reeves, R. D. and Smith, J. A. C. (2000). Metal hyper accumulator plants. Lewis

    Publisher, Boca Raton, F.L. (USA), 85 – 107.

    Boyle, R.W. (1981). Geochemistry of nickel In : Effects of nickel in the Canadian environment, Ottawa, National

    Research Council of Canada, 31 – 34.

    Chau, Y. K. and Cordeiro, O. T. R. K. (1995). Occurrence of nickel in the Canadian environment. Environ. Rev. 3 : 95 – 120

    Chauhan, S. S., Thakur, R. and Sharma, G. D. (2008). Nickel: its availability and reactions in soil. J. Indl. Polln. Ctrl. 24(1) : 57 – 62.

    Drake, H. L. (1982). Occurrence of nickel in carbonmonoxide dehydrogenase from Clostridium pasteurianum and Clostridium thermoaceticum. J. Bacteriol. 149: 561 – 566

    EPA, (2002). Nickel and nickel compound. Poll. Prevent. Fact Sheet, 96: 1 – 2

    Fordsmand, J. J. S. (1997). Toxicity of nickel to soil organisms in Denmark, Rev. Environ. Contam. Toxicol. 148: 1 – 31

    Gilani, S. H. and Marano, M. (1980). Congenital abnormalities in nickel poisoning in chick embryos. Arch. Environ. Contam. Toxicol. 9: 17 – 22

    Grimsrud, T. K., Berge, S.R., Martinsen, J. I. and Andersen, A. (2003). Lung cancer incidence among Norwegian

    nickel-refinery workers. J. Environ. Monit. 5: 190 – 197. 287

    Hausinger, R. P. (1993). Nickel and human health: Current perspectives In: Biological utilization of nickel, [Nieboer E, Nriagu (eds)], Wiley and Sons, New York, 21 – 36.

    Hostynek, J. J. and Maibach, H. I. (2002). Nickel and the skin, CRC Press, Boca Raton, 1 – 249.

    Howard, H. (2003). The environment and human health, Ed. Michael Mc. Cually, MIT Press, 98 – 115.

    International Agency for Research on Cancer (IARC) (1990). Monographs on the evaluation of carcinogenic risks to humans, Chromium, Nickel and Welding, 49, IARC Scientific publications, Lyon, France, 257 – 445.

    International Programme on Chemical Safety (IPCS), (1991). Environmental Health Criteria Series #108, Nickel,

    World Health Organization, Geneva, 383.

    International Programme on Chemical Safety (IPCS), (1992). Environmental Health Criteria, Nickel, World Health Organization, Geneva, 108.

    Kasprzak, K. S. (1987). Nickel, Advances in Modern Environ. Toxicol., 11, 145 – 183.

    Kasprzak, S., Sunderman, F. W. and Salnikow, K. (2003). Nickel carcinogenesis, Mut. Res. 533: 67 – 97

    Khan, S. U. and Moheman, A. (2006). Effect of heavy metals (cadmium and nickel) on the seed germination, growth and metals uptake by chilli (Capsicum frutescens) and sunflower plants (Helianthus annus). Poll. Res. 25(1): 99 – 104

    King, M.M., Lynn, K.K. and Huang, C.Y. (1985). Activation of the calmodulin-dependant phosphoprotein phosphatase by nickel ions, In: Brown SS, Sunderman FW Jr., ed. Progress in nickel toxicology. Proceedings of

    the 3rd International Conference on Nickel Metabolism and Toxicology, Paris, 4-7 September, Oxford, Blackwell Scientific Publications, 117 – 122.

    Kramer, U., Howells, C. J. D., Charnock, J. M., Baker, A. J. M. and Smith, J. A. C. (1996). Free histidine as a metal chelator in plants that accumulate nickel, Nature, 379: 635 – 638.

    Matlock, M.M., Howerton, B.S and Atwood, D.A. (2002). Chemical precipitation of heavy metals from acid mine

    drainage. Water Res. 36: 4757 – 4764. More, T. G., Rajput, R. A. and Bandila, N. N. (2003). Trace element contamination in a coastal aquifer of Andhra Pradesh. J. Indl. Polln. Ctrl. 26: 181 – 202.

    National Academy of Sciences (NAS), (1975). Medical and biological effects of environmental pollutants, Nickel,

    National Research Council, National Academy of Sciences, Washington, 277.

    Ross, S. M. (1994). Sources and forms of potentially toxic metals in soil – plant systems, In: Toxic metals in soil – plant systems (Ed : S M. Ross), Wiley and Sons, New York, 3 – 25.

    Salniko, K., Davidson, T., Zhang, Q., Chen, L. C., Su, N. and Costa, M. (2003). The involvement of hypoxia -

    inducible transcription factor 1 dependent pathway in nickel carcinogenesis, Cancer Res. 63: 3524 – 3530

    Schnegg, H.A. and Kirchgessner, M. (1980). Toxic effects of trace elements on the reproduction of mice and rats,

    Arch. Environ. Hlth., 23: 102 – 106

    Sevin, I. F. (1980). Nickel, Metals in the environment, Academic Press, London, 263 – 291.

    Sharma, R. K. and Agarwal, M. (2005). Biological effects of heavy metals: An overview, J. Environ. Biol. 26(2):

    301 – 313

    Sigel, H. and Sigel, A. (1988). Nickel and its role in biology, Metal ions in biological systems, Marcel Dekker, New York, 488

    Sunderman, F. W., Sullivan, J. B. and Krieger, G. R. (2001). Nickel in clinical environmental health and toxic

    exposures, Williams and Wilkins, Baltimore, 905 – 910.

    Tikhomirov, F. A., Kuznetsova, N. N. and Magina, L.G. (1987). Effect of nickel on plants in a sod-podzolic soil.

    Agrokhimiya. 8: 74 – 80.

    1. S. Environmental Protection Agency (USEPA), (1980). Ambient water quality criteria for nickel, EPA Report,


    1. S. Public Health Service (USPHS) (1993). Toxicological profile for nickel, U.S. Public health service, Agency for toxic substances and disease registry, Atlanta, Georgia, 158.

    Verkleji, J. A. C. (1993). The effects of heavy metals stress on higher plants and their use as biomonitors In: Plant as bioindicators: Indicators of heavy metals in the terrestrial environment, Markert, B edition, VCH, New York, 415 – 424.

    Welch, R. M. (1995). Micronutrient nutrition of plants. Crit. Rev. Plant Sci. 14: 49 – 82

    Wintz, M., Fox, T. and Vulpe, C. (2002). Functional genomics and gene regulation in biometal research. Bull. Environ. Contam. Toxicol. 30: 765 – 768.

    Wood, B. W. and Reilly, C. C. (2007). Interaction of nickel and plant diseases In: Datnoff LE, Elmer, WH, Huber, DM., editors, Mineral nutrition and plant disease, Minneapolis, American Phytopathological Society Press, 217-247.

    Yokoi, K., Uthus, E. O. and Nielson, F. H. (2002). The essential use of nickel affects physiological functions regulated by the cyclic - GMP signal transduction system, Proceedings of the 7th international symposium on metal ions in biology and medicine, St. Petersburg, Russia, 5 – 9.

    Zienolddiny, S., Ryberg, D. and Haugen, A. (2000). Induction of microsatellite mutations by oxidative agents in human lungs cancer cell lines, Carcinogenesis, 74, 1521 – 1526.